Gene Therapy in Neurology

Antisense Therapy in Neurology

Antisense therapy is an approach to fighting diseases using short DNA-like molecules called antisense oligonucleotides. Recently, antisense therapy has emerged as an exciting and promising strategy for the treatment of various neurodegenerative and neuromuscular disorders. Previous and ongoing pre-clinical and clinical trials have provided encouraging early results. Spinal muscular atrophy (SMA...

Recent Advances in Hemophilia Gene Therapy

Heterogeneous loss of function mutations at F8 and F9 genes causes X-linked recessive bleeding disorders, hemophilia A (HA) and hemophilia B (HB), respectively. HA is clinically indistinguishable from HB and accounts for more than 80% of hemophilia cases; the former affects 1/5000 and the latter 1/25000 male births worldwide. In Iran, it is estimated that around 4300 HA and 900 HB patients are ...

Applications of Electrical Impedance Tomography in Neurology

Introduction: Electrical impedance tomography (EIT) is a non-invasive technique utilized in various medical applications, including brain imaging and other neurological diseases. Recognizing the physiological and anatomical characteristics of organs based on their electrical properties is one of the main applications of EIT, as each variety of tissue structure has its own electrical characteris...

ژن درمانی Gene Therapy

Plasmapheresis therapy for immune-mediated diseases in neurology: literature review

Plasmapheresis is a therapeutic apheresis procedure of high complexity, often available only in reference centers. This availability allows the medical team to offer the patient a treatment that has been proven effective for morbidities of major impact from the clinical point of view, reflecting directly on the patient’s quality of life. This literature review shows that many immune-mediated ne...